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thesistopics [2016/12/12 18:33]
Jens Stoye
thesistopics [2018/04/19 09:41] (current)
Jens Stoye
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 </​WRAP>​ </​WRAP>​
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-===== The ABCs of MLE with DCJ ===== 
-Jens Stoye, Pedro Feijão (Simon Fraser University, Vancouver)\\ Master ​ 
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-For faster Maximum Likelihood Estimation (MLE) of the Double Cut and Join (DCJ) distance, we want to develop and test a closed formula for the exact number of DCJ sorting scenarios of length //k// = //d//+1 between two genomes //A// and //B//, where //d// is the DCJ distance between //A// and //B//. This could, for example, be done by studying the set of defective parking functions. 
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-===== Evolution of Cilia-building Proteins ===== 
-Jens Stoye, Roland Wittler, Heymut Omran (Münster University Hospital)\\ Master ​ 
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-In collaboration with the Münster University Hospital we want to study the phylogeny of proteins involved in the structure of motile cilia, whose defect can cause a number of severe heritable diseases. The project involves the detection of homologs (and their differentiation into orthologos and paralogs) of the relevant proteins in various species, a prediction of their evolution using various tools for phylogenetic analysis, the study of their genomic context, and a consistency check based on phenotypic/​morphological data. 
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-===== Improvement of Exome Analysis ===== 
-Jens Stoye, Roland Wittler, Heymut Omran (Münster University Hospital)\\ Master ​ 
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-In collaboration with the Münster University Hospital we plan to improve and develop methods for exome sequencing support. This involves the study of existing and development of new analysis methods: quality control, annotation (including deletion and duplication prediction) and software engineering. Programming skills in Python or Java are necessary. 
  
  
thesistopics.txt · Last modified: 2018/04/19 09:41 by Jens Stoye