Bachelor and Master Thesis Topics within the AG Genome Informatics

The following is a (probably incomplete) list of thesis topics offered within the Genome Informatics group. If you are interested in working on one of these (or anything else in Genome Informatics), please contact the responsible group members or see Prof. Jens Stoye.

Improvement of Sequence-to-Graph Alignment (Bachelor)

Tizian Schulz (Please also refer to the project page: PLAST)

PLAST is a new heuristic method to find maximum scoring local alignments of a DNA query sequence to a pangenome represented as a compacted colored de Bruijn graph. The first method has been published here, but there exist various ideas how to improve the method. Some are well suited for a Bachelor thesis. Contact Tizian for details.

Medical Bioinformatics Projects in Australia (Master)

Jens Stoye, Lutz Krause (University of Queensland Diamantina Institute, Brisbane, Australia)

In collaboration with the Computational Clinical Genomics Group at the University of Queensland Diamantina Institute, Brisbane, Australia, we develop and apply bioinformatics and data-mining methods in the context of biomedical research. Student projects are available in the context of biomarker discovery for cancer, genome-wide epigenetic association studies, analysis of next-generation sequencing data, mining and visualizing the human microbiota, evolutionary genomics of human parasites, calling structural variants from next-generation sequencing data and genome-wide association studies (GWAS).