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thesistopics [2023/03/27 15:15]
rwittler 		thesistopics [2024/02/19 14:00]
leonard [(Runtime) Heuristic for the Fast Comparison of Genomes (Bachelor)]
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-===== (Runtime) Heuristic for the Fast Comparison of Genomes (Bachelor) =====+===== (Runtime) Heuristic for the Fast Comparison of Genomes (Bachelor/Master) =====
 [[ https://​ekvv.uni-bielefeld.de/​pers_publ/​publ/​PersonDetail.jsp?​personId=129443261 | Leonard Bohnenkämper]] (Also refer to the [[ https://​gitlab.ub.uni-bielefeld.de/​gi/​ding | gitlab1]]/ [[ https://​gitlab.ub.uni-bielefeld.de/​lbohnenkaemper/​dingiiofficial | 2]]) [[ https://​ekvv.uni-bielefeld.de/​pers_publ/​publ/​PersonDetail.jsp?​personId=129443261 | Leonard Bohnenkämper]] (Also refer to the [[ https://​gitlab.ub.uni-bielefeld.de/​gi/​ding | gitlab1]]/ [[ https://​gitlab.ub.uni-bielefeld.de/​lbohnenkaemper/​dingiiofficial | 2]])
  
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 {{ :​sans.png?​nolink|}}SANS is an efficient method for alignment-free,​ whole-genome based phylogeny estimation that follows a pangenomic approach to efficiently calculate a set of splits in a phylogenetic tree or network. Splits Tree is a tool to visualize such split networks. In this project, the output of SANS should be simplified by replacing individual, textual genome labels by colored bullets that indicate phylogenetic subgroups (or other properties),​ see example. {{ :​sans.png?​nolink|}}SANS is an efficient method for alignment-free,​ whole-genome based phylogeny estimation that follows a pangenomic approach to efficiently calculate a set of splits in a phylogenetic tree or network. Splits Tree is a tool to visualize such split networks. In this project, the output of SANS should be simplified by replacing individual, textual genome labels by colored bullets that indicate phylogenetic subgroups (or other properties),​ see example.
  
 +===== Horizontal Gene Transfer Detection (Master) =====
 +[[https://​ekvv.uni-bielefeld.de/​pers_publ/​publ/​PersonDetail.jsp?​personId=70863414|Tizian Schulz]] ​ or
 +[[https://​ekvv.uni-bielefeld.de/​pers_publ/​publ/​PersonDetail.jsp?​personId=3721521 | Roland Wittler]] or
 +[[ https://​ekvv.uni-bielefeld.de/​pers_publ/​publ/​PersonDetail.jsp?​personId=129443261 | Leonard Bohnenkämper]]
 +
 +Horizontal Gene Transfers (HGTs) are events that transfer genetic material from one lineage to another. HGTs are especially common in bacteria and particularly relevant for the spreading of (antibiotic) resistance factors among microbes.
 +SANS is an efficient method for the construction of phylogenies and as a byproduct allows to find candidate sequences that might have been part of a HGT (see also [[https://​doi.org/​10.1186/​s13015-020-00164-3 | Section "​Drosophila"​]]). There are some ideas how to automatize the process of finding and verifying such HGT candidates, which can be developed into a master thesis - or you can even bring your own!